马力耕

教授

博士生导师

生物科学

首都师范大学生命科学学院

马力耕，男，1965年出生。教授，博士生导师。1987毕业于河北师范大学生物学系，获学士学位；1990毕业于河北师范大学生物学系植物生理学专业，获硕士学位；1997 毕业于中国农业大学生物学院生物化学专业，获博士学位。

论文情况

论文标题为：《MicroRNAs and their targets from Arabidopsis to rice: half conserved and half diverged》，None

论文标题为：《The SNW Domain of SKIP Is Required for Its Integration into the Spliceosome and Its Interaction with the Paf1 Complex in Arabidopsis.》，Abstract SKIP is a conserved protein from yeasts to plants and humans. In plant cells, SKIP is a bifunctional regulator that works in the nucleus as a splicing factor by integrating into the spliceos...

论文标题为：《SKIP Confers Osmotic Tolerance during Salt Stress by Controlling Alternative Gene Splicing in Arabidopsis.》，Abstract Deciphering the mechanisms underlying plant responses to abiotic stress is key for improving plant stress resistance. Much is known about the regulation of gene expression in response to sal...

论文标题为：《The ATP-Binding Cassette Transporter ABCB19 Regulates Postembryonic Organ Separation in Arabidopsis》，The phytohormone auxin plays a critical role in plant development, including embryogenesis, organogenesis, tropism, apical dominance and in cell growth, division, and expansion. In these processes, th...

论文标题为：《USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing》，Post-translational histone modifications play important roles in regulating chromatin structure and function. Histone H2B ubiquitination and deubiquitination have been implicated in transcriptional re...

论文标题为：《A Companion Cell–Dominant and Developmentally Regulated H3K4 Demethylase Controls Flowering Time in Arabidopsis via the Repression of FLC Expression》，Flowering time relies on the integration of intrinsic developmental cues and environmental signals. FLC and its downstream target FT are key players in the floral transition in Arabidopsis. Here, we c...

论文标题为：《Overexpression of a histone H3K4 demethylase, JMJ15, accelerates flowering time in Arabidopsis》，The methylation of histone 3 lysine 4 (H3K4) is essential for gene activation. Flowering Locus C (FLC), an important flowering repressor, quantitatively regulates flowering time in Arabidopsis and its...

论文标题为：《SKIP Is a Component of the Spliceosome Linking Alternative Splicing and the Circadian Clock in Arabidopsis》，Circadian clocks generate endogenous rhythms in most organisms from cyanobacteria to humans and facilitate entrainment to environmental diurnal cycles, thus conferring a fitness advantage. Both transc...

论文标题为：《Overexpression of AtBMI1C, a Polycomb Group Protein Gene, Accelerates Flowering in Arabidopsis》，Polycomb group protein (PcG)-mediated gene silencing is emerging as an essential developmental regulatory mechanism in eukaryotic organisms. PcGs inactivate or maintain the silenced state of their tar...

论文标题为：《Conservation and divergence of the histone H2B monoubiquitination pathway from yeast to humans and plants》，Histone ubiquitination plays a critical role in the regulation of transcription, and histone H2B monoubiquitination (H2Bub1) is mainly associated with transcriptional activation. Recent studies in yea...

论文标题为：《Characterization of the genome expression trends in the heading-stage panicle of six rice lineages》，a b s t r a c t a r t i c l e i n f o To study how changes in gene regulation shape phenotypic variations in rice, we performed a comparative analysis of genome expression in the heading-stage panicle...

论文标题为：《Histone H2B Monoubiquitination in the Chromatin of FLOWERING LOCUS C Regulates Flowering Time in Arabidopsis》，Ubiquitination is one of many known histone modifications that regulate gene expression. Here, we examine the Arabidopsis thaliana homologs of the yeast E2 and E3 enzymes responsible for H2B monoubiqu...

项目情况

项目标题为：《植物基因组层面的可变剪切研究》，项目类型为：国家级项目;其他项目;2013年植物基因组学国家重点实验室开放课题

项目标题为：《细胞信息》，项目类型为：国家杰出青年科学基金

项目标题为：《细胞外钙调素对基因表达调控研究》，项目类型为：面上项目

项目标题为：《细胞外钙调素对花粉萌发调控作用的信号转导机理研究》，项目类型为：青年科学基金项目

项目标题为：《基因可变剪接参与拟南芥生态型间杂交不亲合调控研究》，项目类型为：面上项目

项目标题为：《植物响应盐碱胁迫的组蛋白修饰和基因转录调控机制》，项目类型为：国家级项目;国家973计划 ;民口973

教育经历

1987年：河北师范大学生物学系学士学位

1990年：河北师范大学生物学系硕士学位

1997年：中国农业大学生物学院博士学位

工作主要经历

2011.12- 今 首都师范大学生命科学学院教授、博士研究生导师

2010.1 - 2011.12河北师范大学生命科学学院教授、博士研究生导师

2005.1 - 2010.1 北京生命科学研究所研究员、博士研究生导师

2000.8 - 2004.12美国耶鲁大学分子、细胞和发育生物学系博士后

1996.6 - 2000.8 河北师范大学生物学系教授（1998年起博士研究生导师）

1990.7 - 1996.6 河北师范大学生物学系助教、讲师

国家自然科学奖二等奖（排名第三）

国家杰出青年基金获得者

全国百篇优秀博士论文提名奖指导教师

河北省自然科学一等奖（排名第二）

教育部科技进步二等奖（排名第二）

教育部霍英东教育基金会高校青年教师研究三等奖

《利用DNA微阵列芯片研究拟南芥光调控发育过程》入选2002年度“中国高等学校十大科技进展”（论文第一作者，获奖排名第三）

中国植物生理学会优秀论文一等奖（排名第一）

北京市中关村高端领军人才

河北省省管优秀专家

河北省有突出贡献的中青年专家

发表的论文被SCI收录超过50篇，被SCI引用总次数超过5000次，其中单篇论文最高引用近400次（Ma et al., Plant Cell 2001），发表的主要论文有：

1.    Wang Z, Li J, Chen S, Heng Y, Chen Z, Yang J, Zhou K, Pei J, He H*, Deng XW*, and Ma LG*. Poaceae-specific MS1 encodes a phospholipid-binding protein for male fertility in bread wheat. PNAS, 2017, in press（*通讯作者）

 2.    Li J, Wang Z, Hu Y, Cao Y and Ma LG*. Polycomb Group Proteins RING1A and RING1B Regulate the Vegetative Phase Transition in Arabidopsis. Front. Plant Sci. 2017, 8: 867. doi: 10.3389/fpls.2017.00867.（*通讯作者）

 3.    Feng, J., Ma, LG*. A Method for Characterizing Embryogenesis in Arabidopsis. Journal of Visualized Experiments, 2017, e55969, doi:10.3791/55969 . （*通讯作者）

 4.    Shang X, Cao Y and Ma LG*. Alternative Splicing in Plant Genes: A Means of Regulating the Environmental Fitness of Plants. Int. J. Mol. Sci. 2017, 18, 432; doi:10.3390/ijms18020432（*通讯作者）

 5.    Feng J, Li R, Ma S, Wu C, Li Y, Cao Y, Ma LG*. Protein N-terminal acetylation is required for embryogenesis in Arabidopsis. Journal of Experimental Botany, 2016,  67 : 4779–4789. （*通讯作者）

 6.    Feng J, Ma LG*. NatA is required for suspensor development in Arabidopsis. Plant Signaling & Behavior, 2016 11:e1231293（*通讯作者）

 7.     Li Y, Xia C, Feng J, Yang D, Wu F, Cao Y, Li L, Ma LG*. The SNW Domain of SKIP Is Required for Its Integration into the Spliceosome and Its Interaction with the Paf1 Complex in Arabidopsis. Molecular Plant. 2016, 9, 1040–1050. （*通讯作者）

 8.    Cao Y, Wen L, Wang Z, Ma LG*. SKIP Interacts with the Paf1 Complex to Regulate Flowering via the Activation of FLC Transcription in Arabidopsis. Molecular Plant, 2015, 8, 1816–1819. （*通讯作者）

 9.     Feng J, Li J, Gao Z, Lu Y, Yu J, Zheng Q, Yan S, Zhang W, He H, Ma LG*, Zhu Z*. SKIP Confers Osmotic Tolerance During Salt Stress by Controlling Alternative Gene Splicing in Arabidopsis. Molecular Plant, 2015, 8,1038–1052. （*通讯作者）

 10.     Ning YQ, Ma ZY, Huang HW, Mo H, Zhao T, Lin Li, Cai T, Chen S, Ma LG and He XJ. Two novel NAC transcription factors regulate gene expression and flowering time by associating with the histone demethylase JMJ14. Nucleic Acids Research, 2015, 43:1469-1484.

 11.     Yu Y, Wang J, Zhang Z, Quan R, Zhang H, Deng XW, Ma LG*, Huang R*. Ethylene promotes hypocotyl growth and HY5 degradation by enhancing the movement of COP1 to the nucleus in the light. PLoS Genetics, 2013, 9: e1004025.doi:10.1371/journal.pgen. 1004025. （*通讯作者）

 12.    Wang J, Yu Y, Zhang Z, Quan R, Zhang H, Ma LG, Deng XW, Huang R. Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic acid synthesis. Plant Cell, 2013, 25:625-36. doi: 10.1105/tpc.112.106880 

 13.    Zhang Z, Jones A, Joo HY, Zhou D, Cao Y, Chen S, Erdjument-Bromage H, Renfrow M, He H, Temps P,.Townes TM, Giles KE, Ma LG, and Wang H. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. 2013, Genes & Development, 27:1581–1595.

 14.    Zhao H., Liu L, Mo H, Qian L, Cao Y, Cui S, Li  X, Ma LG*.The ATP-binding cassette transporter ABCB19 regulates postembryonic organ separation in Arabidopsis. PLoS ONE, 2013, 8(4): e60809. doi:10.1371/journal. pone. 0060809. （*通讯作者）

 15.    Wang X, Wu F, Xie Q, Wang H, Wang Y, Yue Y, Gahura O, Ma  S, Liu L, Cao Y, Jiao Y, Puta F, McClung CR, Xu X, and Ma LG*. SKIP is a component of the spliceosome linking alternative splicing and the circadian clock in Arabidopsis. Plant Cell, 2012, 24: 3278–3295. （*通讯作者）

 16.    Yang HC, Cao Y, Han ZF, Mo HX, Fan D, Li H, Liu L, Yue YL, She C, Chai JJ, and Ma Ma LG*. A companion cell-dominant and developmentally-regulated H3K4 demethylase controls flowering time in Arabidopsis via the repression of FLC expression. PLoS Genetics, 2012, 8:e1002664. （*通讯作者）

 17.    Fan  D, Dai Y, Wang X, Wang Z, He H, Yang H, Cao Y, Deng XW, and Ma LG*.  IBM1, a JmjC domain-containing histone demethylase, is involved in the regulation of RNA-directed DNA methylation through the epigenetic control of RDR2 and DCL3 expression in Arabidopsis. Nucleic Acids Research, 2012, 40:8905-8916. （*通讯作者）

 18.    Zhao H, Wang X, Zhu D, Cui S, and Ma LG*. A single amino acid substitution in a IIIF bHLH transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis. Journal of Biological Chemistry, 2012, 287:14109-14121. （*通讯作者）

 19.    Yang HC, Mo HX, Fan D, Cao Y, Cui SJ, and Ma LG*. Overexpression of a histone H3K4 demethylase, JMJ15, accelerated flowering time in Arabidopsis. Plant Cell Reports, 2012, 31:1297-1308. （*通讯作者）

 20.    Zhao H, Li X, and Ma LG*. Basic helix-loop-helix transcription factors and epidermal cell fate determination in Arabidopsis. Plant Signaling & Behavior, 2012, 7:1-5.（*通讯作者）

 21.    Wang X, Ma LG*. Unraveling the circadian clock in Arabidopsis. Plant Signaling & Behavior, 2012, 8(2): pii: e23014. （*通讯作者）

 22.    Cao Y and Ma LG*. Conservation and divergence of the histone H2B monoubiquitination pathway from yeast to humans and plants. Frontier Biology, 2011, 6:109-117. （*通讯作者）

 23.    Li W, Wang Z, Li J, Yang H, Cui S, Wang X, Ma LG*. Overexpression of AtBMI1C, a polycomb group protein gene, accelerates flowering in Arabidopsis. PLoS ONE 2011, 6: e21364. doi:10.1371/ journal.pone. 0021364（*通讯作者）

 24.    Lu SX, Liu H, Knowles SM, Li J, Ma LG, Tobin EM and Lin C. A role for protein kinase CK2 alpha subunits in the Arabidopsis circadian clock. Plant Physiology 2011, 157:1537-1545.

 25.    Ma LG. MicroRNAs and their targets from rice to Arabidopsis : half conserved and half diverged (invited comments). Frontier Biology, 2010, 5 :3-4.

 26.    Jiao YL, Tausta SL , Gandotra N , Sun N, Liu T, Clay NK, Ceserani T, Chen MQ, Ma LG, Holford M, Zhang HY , Zhao HY, Deng XW, Nelson T. A transcriptome atlas of rice cell types uncovers cellular, functional and developmental hierarchies. Nature Genetics, 2009, 41:258-263.

 27.    Cao Y, Dai Y, Cui SJ, Ma LG*. Histone H2B monoubiquitination is required for histone H3K4 methylation of FLC/MAFs chromatin and flowering time control in Arabidopsis. Plant Cell, 2008，20:2586-602. （*通讯作者）

 28.    Wu Y, Zhu Z, Ma LG, Chen M. The preferential retention of starch synthesis genes reveals the impact of whole-genome duplication on grass evolution. Mol. Biol. Evol., 2008, 25:1003-1006. doi: 10.1093/molbev/msn052

 29.  Wang XX, Ma LG*. Polycomb-group (Pc-G) proteins control seed development in Arabidopsis (Invited review). Journal of Integrative Plant Biology, 2007, 49: 52-59. （*通讯作者）

 30.    Qin G, Gu H, Ma LG, Peng Y, Deng XW, Chen Z, Qu LJ. Disruption of phytoene desaturase gene results in albino and dwarf phenotypes in Arabidopsis by impairing chlorophyll, carotenoid, and gibberellin biosynthesis. Cell Research, 2007, 17:471-482.

 31.   Jiao Y*, Ma LG*, Strickland E， Deng XW. Conservation and Divergence of Light-Regulated Genome Expression Patterns during Seedling Development in Rice and Arabidopsis. Plant Cell, 2005，17:3239-3256 (*并列第一作者).

 32.     Ma LG, Chen C, Liu X, Jiao Y, Su N, Li L, Wang X, Cao M, Sun N, Zhang X, Bao J, Li J, Pedersen S, Bolund L, Zhao H, Yuan L, Wong GKS, Wang J, Deng XW, and Wang J. An analysis of transcriptional regulation of the rice genome and its comparison to Arabidopsis. Genome Research，2005, 15：1274-1283.

 33.    Ma LG, Sun N, Liu X, Jiao Y, Zhao H, Deng XW. Organ-specific genome expression atlas during Arabidopsis development. 2005, Plant Physiology,  138:80-91.

 34.    Shen YP, Feng SH, Ma LG, Lin RC, Qu LJ, Chen ZL, Wang HY, Deng XW. Arabidopsis FHY1 protein stability is regulated by light via phytochrome a and 26S proteasome. Plant Physiology, 2005, 139:1234-124.

35.    Feng S*, Ma LG*, Wang X, Xie D, Dinesh-Kumar S. P., Wei N, and Deng XW. The COP9 Signalosome Physically Interacts with SCFCOI1 and Modulates Jasmonate Responses. Plant Cell, 2003, 15:1083-1094 (*并列第一作者).

 36.    Ma LG, Zhao H, Deng XW. Analysis of the mutational effects of the COP/DET/FUS loci on genome expression profiles reveals their overlapping yet not identical roles in regulating Arabidopsis seedling development. Development, 2003, 130: 969-981.

 37.    Wu P, Ma LG, Hou XL, Wang MY, Wu YR, Liu FY, Deng XW Phosphate starvation triggers distinct alterations of genome expression in Arabidopsis roots and leaves. Plant Physiology, 2003, 1321260-1271.

 38.    Ma LG, Gao Y, Qu LJ, Chen ZL, Li JM, Zhao H, Deng XW. Genomic evidence for COP1 as a repressor of light-regulated gene expression and development in Arabidopsis. Plant Cell, 2002，14: 2383-2398.

 39.    Wang H*, Ma LG*, Habashi J, Li JM, Zhao H, Deng XW. Analysis of far-red light-regulated genome expression profiles of phytochrome A pathway mutants in Arabidopsis. Plant Journal, 2002, 32:723-734. (*并列第一作者).

 40.    Holm M, Ma LG, Qu LJ, Deng XW. Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis. Genes & Development, 2002, 16: 1247-1259.

 41.    Ma LG, Li JM, Qu LJ, Hager J, Chen ZL, Zhao H, Deng XW. Light control of Arabidopsis development entails coordinated regulation of genome expression and cellular pathways. Plant Cell, 2001, 13: 2589-2607.

 42.  Wang H, Ma LG, Li JM, Zhao H, Deng XW. Direction interaction of Arabidopsis cryptochromes with COP1 in light control development. Science, 2001, 294:154-158.

 43.    Ma LG, Xu X, Cui S, Sun D. The presence of a heterotrimeric G protein and its role in signal transduction of extracellular calmodulin in pollen germination and tube growth. Plant Cell, 1999 11:1351–1363.