聂舟_高校科技成果转化对接服务平台

湖南大学二级教授，博士生导师。

现任湖南大学研究生院副院长兼学位办主任，生物大分子化学生物学湖南省重点实验室主任，第十二届湖南省政协委员。

入选国内高层次人才计划，荣获湖南省优秀科技工作者、优秀研究生导师，中国化学会青年化学奖，卢嘉锡优秀导师奖等奖励。

主持国家自然科学基金杰出青年基金、重点项目、优秀青年基金和国家重点研发计划项目课题等国家级科研项目。

围绕生物医学中关键机制，如表观遗传及细胞信号传导等开展深入探索，主要开展以下两方面研究：1. 基于功能蛋白质和核酸的生物传感新方法；2. 化学手段调控细胞行为和命运。自2009年以来作为通讯作者在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Science Advances, Nano Lett., ACS. Nano., Nucleic Acids Res., Chem. Sci., Anal. Chem. 等国际国内高水平期刊上发表学术论文100多篇，近五年论文他引2000多次。获国家发明专利授权2项，受邀为Springer出版社撰写英文学术专著2章。

教育背景

1998-2002 南开大学生命科学学院理学学士

2002-2007 中国科学院化学研究所理学博士

工作履历

2019-至今湖南大学研究生院副院长兼学位办主任

2015-2019 湖南大学化学化工学院副院长

2011-2012 Purdue University(普渡大学) 博士后

2011-至今湖南大学化学化工学院教授博士生导师

2008-2010 湖南大学化学化工学院副教授

2007-2008 湖南大学化学化工学院讲师

2021年湖南省优秀科技工作者

2021年湖南省优秀研究生导师

2016年中国化学会青年化学奖

2015年卢嘉锡优秀导师奖

近年来以通讯作者在J. Am. Chem. Soc.（2）, Angew. Chem. Int. Ed.（7）, Science Advances, Nano Lett., ACS. Nano., Nucleic Acids Res., Chem. Sci., Anal. Chem等国际国内高水平期刊上发表学术论文100多篇，近五年论文他引2000多次。获国家发明专利授权2项，受邀为Springer出版社撰写英文学术专著2章。

Selected publications:

J.H. Zhang＃, H.Y. Li＃, B. Lin, X.Y. Luo, P. Yin, T. Yi, B.B. Xue, X.-Li. Zhang, H.Z. Zhu, Zhou Nie*. Development of near-infrared nucleic acid mimics of fluorescent proteins for in vivo imaging of viral RNA with turn-on fluorescence. J. Am. Chem. Soc., 2021, 143, 19317-19329.

K. Shi, S.Y. Xie, R.Y. Tian, S. Wang, Q. Lu, D.H. Gao, C.Y. Lei, H.Z. Zhu, Z. Nie*. A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics.Science Advances, 2021, 7, eabc7802.

H. Li, J. Gao, L. Cao, X. Xie, J.H. Fan, H.D. Wang, H.-H. Wang*, Z. Nie*. A DNA molecular robot that autonomously walks on the cell membrane to drive cell motility. Angew. Chem. Int. Ed., 2021, 60, 26087-26095. (Very Important Paper, Inside Back Cover)

J.H. Zhang, Z.Y. Qiu, J.H. Fan, F. He, W.Y. Kang, S.H. Yang, H.-H. Wang*, J. Huang*, Z. Nie*. Scan and Unlock: A programmable DNA molecular automaton for cell-selective activation ligand-based signaling. Angew. Chem. Int. Ed., 2021, 60, 6733-6743. (Hot Paper)

X.H. Zhu, R. Tang, S.G. Wang, X.Y. Chen, J.J. Hu, C.Y. Lei, Y. Huang, H.H. Wang, Z. Nie*, S.Z. Yao. Protein@inorganic nanodumpling system for high-loading protein delivery with activatable fluorescence and nagnetic resonance bimodal imaging capabilities. ACS Nano, 2020, 14, 2172-2182.

X.Y. Luo＃, B.B. Xue＃, G.F. Feng＃, J.H. Zhang, B. Lin, P. Zeng, H.Y. Li, H.B. Yi, X.-L. Zhang, H.Z. Zhu*, Z. Nie*. Lighting up the native viral RNA genome with a fluorogenic probe for the live-cell visualization of virus infection. J. Am. Chem. Soc., 2019, 141, 5182-5191.

G.F. Feng＃, X.Y. Luo＃, X. Lu, S.Y. Xie, L. Deng, W.Y. Kang, F. He, J.H. Zhang, C.Y. Lei*, B, Lin, Y. Huang, Z. Nie*, S.Z. Yao. Engineering of nucleic acids and synthetic cofactors as holo sensors for probing signaling molecules in the cellular membrane microenvironment. Angew. Chem. Int. Ed., 2019, 58, 6590-6594. (Very Important Paper, Back Cover)

M. Wang, F. He, H. Li, S.H. Yang, J.H. Zhang, P. Ghosh, H.-H. Wang*, Z. Nie*. Near-infrared light-activated DNA-agonist nanodevice for nongenetically and remotely controlled cellular signaling and behaviors in live animals. Nano Lett., 2019, 19, 2603-2613.

H. Li, M. Wang, T.H. Shi, S.H. Yang, J.H. Zhang, H.-H. Wang*, Z. Nie*. A DNA-mediated chemically induced dimerization (D-CID) nanodevice for nongenetic receptor engineering to control cell behavior. Angew. Chem. Int. Ed., 2018, 57,10226-10230. (Hot paper)

Y. Li, S.J. Sun, L. Fan, S.F. Hu, Y. Huang, K. Zhang, Z. Nie*, S.Z. Yao. Peptide logic circuits based on chemoenzymatic ligation for programmable cell apoptosis. Angew. Chem. Int. Ed., 2017, 56, 14888-14892.

Z. Nie*, P.F. Wang, C. Tian, C.D. Mao*. Synchronization of two assembly processes to build responsive DNA nanostructures. Angew. Chem. Int. Ed., 2014, 53, 8402-8405.

C.Y. Lei, Y. Huang, Z. Nie*, J. Hu, L.J. Li, G.Y. Lu, Y.T. Han, S.Z. Yao. Supercharged fluorescent protein as a versatile probe for homogenous DNA detection and methylation analysis. Angew. Chem. Int. Ed., 2014, 53, 8358-8362. (Hot Paper)

G.F. Feng, C. Luo, H.B. Yi, L. Yuan, B. Lin, X.Y. Luo, X.X. Hu, H.-H. Wang, C.Y. Lei, Z. Nie*, S.Z. Yao. DNA mimics of red fluorescent proteins (RFP) based on G-quadruplex-confined synthetic RFP chromophores. Nucleic Acids Res., 2017, 45, 10380-10392.

W. Li, Y. Li, Z.L. Liu, B. Lin, H.B. Yi, F. Xu, Z. Nie*, S.Z. Yao. Insight into G-quadruplex-hemin DNAzyme/RNAzyme: adjacent adenine as the intramolecular species for remarkable enhancement of enzymatic activity. Nucleic Acids Res., 2016, 44, 7373-7384.